Showcase

During my internship, I collaborated with scientists and entrepreneurs at IU, exploring life sciences and innovation from “Bench to Bedside.” The internship exposed me to research and medical advancements at Indiana University School of Medicine, whe ... re I had hands-on experiences in various core facilities. I gained insights into high-throughput genomics services in the Medical Genomics facility, including next-generation sequencing, single-cell analytics, and spatial transcriptomics. This exposure enhanced my understanding of the latest techniques in medical genomics and their applications. At the Chemical Genomics Facility, led by Dr. Waffo, I explored the use of RNA phage display technology for biomedical purposes. The lab utilizes the Q-beta (Q?) virus phage platform to map and display functional domains of SARS-COV. This research is important for understanding viral pathogenesis and enhancing diagnostics and therapeutics for infectious diseases. Additionally, my involvement in the Behavioral Phenotyping Core provided exposure to the study of animal behaviors, contributing to a broader understanding of research methodologies. My comprehensive internship at IUSM has broadened my understanding of medicine and innovation, enabling me to contribute to meaningful research. It provided a deep dive into diverse life sciences within a collaborative environment that shaped my interest in advancing healthcare through discovery. Read more

During this internship, research activities focus on Parkinson's disease. Parkinson's disease is a progressive disorder of the central nervous system that affects movement. Additionally, patients with Parkinson's suffer from non-motor symptoms, quest ... ion their spirituality, lose joy and meaning in life, and burden care partners. One local Parkinson's Clinic surveys patients to assess their unmet non-motor symptoms, struggles with spirituality, and loss of joy and meaning. This showcase highlights patients with Parkinson's disease who grapple with the loss of joy and meaning in their lives. The research aims to determine the demographic and clinical characteristics associated with losing joy and meaning in life. It uses the survey responses, demographics, and clinical characteristics to answer this question. Read more

Brain Safe is a research study approved by IU Health that is focused on providing educational materials about medication safety. Participants will have 3 meetings by phone over the course of the study, an initial Baseline, a ?6 month midterm, and a c ... oncluding? 12 month follow up. Over the course of the study, participants will complete assessments and use a phone app to help track medication?. Through careful tracking, we can help care providers and patients make better decisions about their medication choices?. Participants of this study are able to fully participate in this study from the comfort of their homes via phone app and phone calls. Due to the fact that participants will not be engaging researchers in person, many methods are employed to reach out to participants when a follow up is needed. These include mail, email, and phone calls. In this presentation, we will explore 3 different formats of participant communication that were employed in this study and the results yielded by these methods. Read more

Diseases like Multiple sclerosis and Alzheimer's are common neurological disorders that affect the nerve system in adults. Alzheimer's is typically caused by abnormal build up of proteins in and around the brain cells. Meanwhile, multiple sclerosis i ... s caused by the malfunction of the immune system. Different technology systems have been created to detect the early onset of neurological diseases. Research groups have developed advanced MRI (Magnetic resonance imaging) & quantitative susceptibility mapping (QSM) techniques which ultimately improves forms of medical imaging and enables people in related fields to analyze neurological diseases with more precise technology. Read more

The rowing study aims to delve into the potential benefits of interval training compared to conventional rowing, particularly concerning its impact on overall muscle fatigue. By scrutinizing this aspect, the study seeks to uncover insights that could ... prove invaluable, especially for individuals with lower muscle fitness levels. Understanding whether interval training induces less muscle fatigue than traditional rowing holds significant promise for enhancing training methodologies and optimizing fitness routines. This investigation holds promise for several reasons. First and foremost, it addresses a critical gap in current understanding regarding the comparative effects of different training modalities on muscle fatigue. By elucidating whether interval training offers a potential advantage in mitigating overall muscle fatigue, the study could pave the way for more tailored and effective exercise prescriptions, particularly for those with lower baseline muscle fitness. Furthermore, the implications extend beyond athletic performance to encompass broader health considerations. Individuals with lower muscle fitness levels, whether due to age, injury, or other factors, often face unique challenges in maintaining an active lifestyle. If interval training indeed proves to be less fatiguing, it could serve as a valuable tool for promoting physical activity and improving overall health outcomes in populations with varying levels of muscle fitness. Overall, the rowing study holds promise not only for advancing scientific knowledge in the realm of exercise physiology but also for offering practical applications that could positively impact the lives of individuals striving to enhance their fitness and well-being. Read more

Retroviruses are a family of RNA viruses that have an enzyme capable of making a DNA copy of the viral RNA, and then infecting it into a host’s cell’s DNA. This virus includes Coronavirus, HIV, Ebola, etc… COVID-19, for example, can enter a host’s ce ... ll by changing Its shape to fit the cell, by binding to the HR2. The main purpose of inhibiting HR2 is to prevent retroviruses from infecting the host using HR2. Read more

The Prevention and Recovery Center for Early Psychosis (PARC) at Eskenazi Hospital works with patients experiencing early psychosis in hopes to identify causes of the disorder, determine best possible treatments, and gain insight into preventing psyc ... hosis from an early age. Dr. Bethany Leonhardt and the PARC team of researchers are involved in an ongoing study aiming to identify the effect of Metacognitive Reflection and Insight Therapy with individuals diagnosed with Early Psychosis (MERIT-EP). MERIT-EP is a therapy approach that allows patients to gain a complex, in-depth understanding of themselves, their diagnosis, and their experiences in order to achieve an individualized definition of recovery. MERIT has previously been used in studies on long-term psychosis patients but has not yet been studied in younger individuals coming to terms with their diagnosis and navigating young adulthood. The MERIT method approach is unique in that it encourages achieving subjective recovery, specific to the individual, rather than its standardized definition. Ultimately, studying this method aims to shift treatment techniques on patients with all levels of psychosis towards a more personalized approach and promote positive long-term outcomes. Read more

In my role at the Sandusky pathology lab, I assist researchers by converting physical slides into digital format, making them accessible on computers. Using specialized software, I analyze specific characteristics like positivity percentages. I also ... support professors by digitizing slides for teaching. I did an independent research project. My focus was on analyzing the impact of chemotherapy using a specific biomarker called p53. This involved examining how clinical treatment affected P53 presence in tumor cells and its impact on patient clinical outcomes. Overall, my experience at the digital pathology lab has been about supporting research and education initiatives while conducting my own investigation into cancer treatment effects. It's been a valuable opportunity to contribute to scientific understanding and enhance my skills in data analysis and interpretation. Read more

Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of insulin-secreting pancreatic ?-cells leading to dysregulation of blood glucose levels. Both genetic and environmental factors contribute to T1D pathogenesis, but the triggeri ... ng events for disease onset are still unknown. The Linnemann lab has shown that autophagy, a process to regulate cell survival and maintenance, is defective in islets during human T1D. Therefore, the lab is now focused on understanding how defective autophagy may contribute to the development of T1D. To understand the various influences of these pathways, the lab selectively knocked out the critical autophagy enzyme, ATG7, in the ?-cells of mice (ATG7??-cell mice). Initial characterization of these mice revealed that all ATG7??-cell mice spontaneously developed diabetes. Initial data gathered in the lab suggests involvement of endoplasmic reticulum (ER) stress response and ER associated degradation pathways. Therefore, to determine whether any of the 3 branches of the ER stress response are preferentially upregulated, we performed immunofluorescence staining on pancreas tissue from ATG7??-cell mice to evaluate these pathways. We also evaluated isolated islets under basal and stress conditions to help determine the mechanism of ATG7??-cell islet loss using incucyte live cell imaging. Read more

Stiffening of the liver, better known as liver fibrosis, is caused by the formation of large amounts of scar tissue. This scar tissue is formed as a result of liver injury, which can be caused by metabolic disorders, obesity, alcohol use, drug use, o ... r viral infection. Hepatic stellate cells (HSCs) will become activated due to this injury and drive fibrogenesis in order to heal the wounded liver. In the case of liver fibrosis, the injury is chronic, and HSCs are persistently activated, leading to the buildup of scar tissue and eventually cirrhosis. Because of the limited understanding of the mechanisms driving this, there are no FDA approved treatment options that will limit or reverse fibrosis. Fibrogenesis is driven by an increased transcription and translation of extracellular matrix proteins by HSCs. This increased translational demand places a stress on HSCs, which activates the unfolded protein response (UPR). One branch of the UPR that regulates translation is PERK signaling, and we have found that PERK signaling increases with HSC activation. We are engineering a PERK KO cell line using CRISPR-Cas9 technology in order to determine if PERK signaling is crucial to HSC activation and fibrogenesis. Read more